| 1862 |
|
Merck produces 1/4 pound of cocaine. 2 |
| 1869 |
|
Seeds from the commercial variety of coca arrived at Kew Gardens. |
| 1870 |
|
Vin Mariani (coca wine) is for sale throughout France, containing 6 mg cocaine per ounce of wine. Exported Vin Mariani contained 7.2 mg per ounce to compete with the higher cocaine content of American competitors. 2 |
| 1870s |
|
Parke,Davis manufactures a fluid extract of coca. 2 |
| 1876 - 1885 |
|
Race walkers in England chew coca leaves to improve their performance. 2 |
| 1883 |
|
Merck produces 3/4 pound of cocaine. 2 |
| 1884 |
|
Cocaine's use as a local anesthetic in eye surgery is popularized. 2 |
| 1884 |
|
Freud publishes On Coca in which he recommends the use of cocaine to treat a variety of conditions including morphine addiction. 2 |
| 1884 |
|
Merck produces 3,179 pounds of cocaine. 2 |
| 1886 |
|
Merck produces 158,352 pounds of cocaine. 2 |
| 1886 |
|
Coca-Cola is first introduced by John Pemberton, containing cocaine laced syrup and caffeine. |
| Late 1880s |
|
Parke,Davis starts to manufacture refined cocaine. 2 |
| c. 1901 |
|
Coca-Cola removed coca from their formula. 2 |
| c. 1905 |
|
Snorting cocaine becomes popular. 2 |
| 1910 |
|
First cases of nasal damage from cocaine snorting are written of in medical literature. 2 |
| 1910 |
|
First cases of nasal damage from cocaine snorting are seen in hospitals. 2 |